Neuroblastoma-targeted Nanoparticles Entrapping siRNA Specifically Knockdown ALK
نویسندگان
چکیده
منابع مشابه
Advances in ALK Targeted Therapy for Neuroblastoma
Significant advances have been made to understand the association between ALK genetic aberrations and disease prognosis in neuroblastoma. ALK targeted therapies are evolving quickly and several randomized controlled trials of ALK inhibitors are underway or nearing completion in adult cancers. Ongoing research will bring new challenges and newer technologies to fully define the pathogenic and pr...
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PURPOSE Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that multiple mechanisms drive resistance to these molecular therapies. We anticipated that detailed mapping of the oncogenic ALK-driven signaling in neuroblastoma can aid to identify potent...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2011
ISSN: 1525-0016
DOI: 10.1038/mt.2011.54